A previous study showed that, among these cytokines, dominant roles in MS pathology have been attributed to TNF-α, IL-1β, IL-6, and IFN-γ, the accumulation of which is associated with MS signs (Brosnan and Raine 1996; Molina-Holgado et al. 2001; Popko et al. 1997). The gene discussed is IFNG; the disease is myeloid sarcoma.