The allele A of rs3790567 and allele C of rs6679356 were overrepresented in PBC patients compared to controls, 30.4% versus 20.7% (p = 0.0009) and 25% versus 17.2% (p = 0.0022), respectively, confirming a significant impact of IL12RB2 polymorphisms on PBC susceptibility (Table 2). This evidence concerns the gene IL12RB2 and primary biliary cholangitis.