Though our study is the first to identify IL12RB2 polymorphisms positively associated with the magnitude of AMA response, this is not the first time that an association between IL12RB2 and high-titre autoantibodies has been found in autoimmune diseases, providing a link between the IL-12/IL-12R axis and the scale of the autoimmune attack at the humoral level. Here, IL12RB2 is linked to autoimmune disease.