They could show that the saturated fatty acid, whose plasma concentration is clearly elevated after a HFD, has a trigger role in the NLRP3-dependent release of IL-1β and IL-18 and prevents regular insulin signaling in target tissues eventuating in insulin resistance, whereas administering unsaturated fatty acids had no influence on inflammasome activation or IL-1β release [55]. The gene discussed is IL18; the disease is Insulin resistance.