WT1 and neoplasm: Gao et al. discovered that miRNAs 15a and 16-1 may function as tumor suppressors to regulate leukemic cell proliferation, potentially by downregulating the WT1 oncogene [12]; pure curcumin was also recently shown to modulate the expression of WT1, partly by upregulating the expression of miR-15a and miR-16-1 in leukemic cells [19].