WT1 and kidney disorder: We found normal WT1 expression in the nuclei of podocytes from biopsies of healthy controls without kidney disease; however, in SSNS patients, WT1 expression was localized to both the nucleus and cytoplasm, whereas WT1 expression is primarily cytoplasmic in SRNS patients, suggesting that delocalization of WT1 from the nucleus can lead to a loss of function as a transcription factor.