Moreover, JPJD can downregulate the total levels of p-Smad2/3 and Snail and upregulate the levels of Smad2/3 in the cytoplasm but have little effect on the total levels of Smad2/3 in the orthotopic CRC tumor tissues (Figure 6, Supplementary Figure 6). This evidence concerns the gene SMAD2 and colorectal carcinoma.