Oct4 showed reduced cytoplasmic accumulation in +veCD pH 7.4 and 6.2 conditions but high accumulation in the cytoplasm at very low pH in all conditions, a phenotype also observed in the gastric cancers (57, 58) and glioblastoma biopsies (see expression in different tumor zones of GBM patient samples—Figure S7 in Supplementary Material). This evidence concerns the gene POU5F1 and glioblastoma.