POU5F1 and neoplasm: Oct4 showed reduced cytoplasmic accumulation in +veCD pH 7.4 and 6.2 conditions but high accumulation in the cytoplasm at very low pH in all conditions, a phenotype also observed in the gastric cancers (57, 58) and glioblastoma biopsies (see expression in different tumor zones of GBM patient samples—Figure S7 in Supplementary Material).