PPARG and neurodegenerative disease: Conversely, in other diseases, PPAR gamma is downregulated while canonical Wnt/beta-catenin is upregulated such as in type 2 diabetes, cancers, and certain neurodegenerative diseases (amyotrophic lateral sclerosis [9], Parkinson's disease, Huntington's disease, multiple sclerosis, and Friedreich's ataxia).