CTNNB1 and neurodegenerative disease: In several diseases, PPAR gamma is upregulated while canonical Wnt/beta-catenin is downregulated [7] such as in arrhythmogenic right ventricular cardiomyopathy (ARVC), osteoporosis, and certain neurodegenerative diseases (Alzheimer's disease [8], bipolar disorder, and schizophrenia).