As anorexia may be present in the pre-cachectic stage and precede significant weight loss and deterioration in physical functioning, future studies should consider treatment with ghrelin in patients with cancer anorexia (for example, in the stage of pre-cachexia) rather than patients with cachexia, in order to study whether significant weight loss and deterioration in physical functioning can be prevented. Here, GHRL is linked to Cachexia.