Of note, ApoJ/Clusterin also binds to Lrp1 (Gil et al., 2013), Vldlr, and Apoer2 (Andersen et al., 2003; Leeb et al., 2014) and alternative receptors Trem2 (Yeh et al., 2016) and Plexin A4 (Kang et al., 2016), yet it is not known how ApoJ/Clusterin interactions with the other LDL receptor family members affects AD pathology. This evidence concerns the gene LDLR and Alzheimer disease.