However, the dramatic inhibitory effect of TNF-α on surfactant protein expression was also reported previously [21]; we found no significant association between the presence of TNF-α-308 A, IL-10-1082 G polymorphisms with wild type allele with need for mechanical ventilator and surfactant and mortality rate in preterm infants who suffered from RDS. The gene discussed is IL10; the disease is newborn respiratory distress syndrome.