We further assessed the differences of the Ezrin autoantibody positivity with clinical variables in ESCC patients, and we found that there were no significant correlations in assay positivity with patient age, gender, tumor size, tumor invasion depth, tumor site, histological grade, lymph node status, TNM stage or early-stage, and advanced stage groups (all P > 0.05, Table 4). The gene discussed is EZR; the disease is neoplasm.