ATP5IF1 and Sepsis: HIF-1α would control IF1 protein level in Clone 9 cells, a non-transformed rat hepatic epithelial cell line, upon hypoxia; however, whereas a decrease in IF1 mRNA expression was paralleled by a decrease in HIF-1α mRNA expression in rat liver during sepsis, direct evidence for the transcriptional regulation of ATPIF1 gene by this transcription factor was not sought37.