CRYGC and nuclear cataract: Combined eight CRYGC mutations in our report, Table 1 showed that CRYGC mutations may be more common in Chinese than in other populations and CRYGC mutations are all associated with nuclear cataract in Chinese, which suggests that screening CRYGC mutations with two pairs of primers followed by intra-familial co-segregation, in Silico analyses and interpretation of the variants according to ACMG guidelines, might be a cost-effective paradigm in the genetic diagnosis of nuclear cataract in Chinese.