Similar effects of the HSP90 inhibitors were observed in several other human bladder carcinoma cell lines, including RT112, RT4, T24, T24T, FLT3, SLT3, UMUC3, UMUC5, UMUC14 (data not shown), suggesting that it is a general antitumor activity for HSP90 inhibitors in human bladder cancer cells. The gene discussed is FLT3; the disease is urinary bladder cancer.