CC-122 is a pleiotropic pathway modifier that also binds CRBN and promotes degradation of Aiolos and Ikaros in diffuse large B-cell lymphoma (DLBCL) T-cells in in vitro and in vivo models and in patients, resulting in both cell autonomous and immune-stimulatory effects. This evidence concerns the gene IKZF1 and diffuse large B-cell lymphoma.