In DLBCL cell lines, both CC-122-induced degradation and short hairpin RNA-mediated knockdown of Aiolos and Ikaros correlate with increased transcription of interferon (IFN)-stimulated genes; this is independent of IFN-α, -β, and -γ production and/or secretion, and results in apoptosis in both activated B-cell (ABC) and germinal centre B-cell DLBCL cell lines [24]. This evidence concerns the gene IKZF1 and diffuse large B-cell lymphoma.