AGT and Hypertension: Different Nox isoforms may have distinct roles even in the same cell type, thought to be related to their coupling to different intracellular signaling pathways or the production of different ROS (superoxide versus hydrogen peroxide).6 This is relevant from a therapeutic perspective because isoform-selective Nox inhibitors are currently being developed.8 Previous work suggested an involvement of Nox1 in the genesis of AngII-dependent hypertension.