Two major genes responsible for HHT are activin A receptor like type 1 (ALK1/ACVRL1) (Johnson et al., 1996), which is a type I receptor of BMP9/10, and endoglin (ENG) (McAllister et al., 1994), which is a co-receptor of ALK1. This evidence concerns the gene ACVRL1 and hereditary hemorrhagic telangiectasia.