As opposed to its immunosuppressant activities, the anti-cancer properties of FTY720 are known to be mainly mediated by its non-phosphorylated form, via inhibition of sphingosine kinase 1 (SphK1) and activation of the protein phosphatase 2A (PP2A), leading to the reduction in cell survival [24, 31, 32]. The gene discussed is SPHK1; the disease is cancer.