Notably,these included genes recurrently mutated in CCA—ARID1A,ARID1B, and PBRM—as well as geneswhose protein products are known to be inhibited byIDH-mutant-generated 2HG, including TET2,TET3, KDM2A, and KDM5B(Xu et al., 2011). Here, KDM5B is linked to cholangiocarcinoma.