ALB and hepatocellular carcinoma: In two tumors, we identified arecurrent P216L mutation in the regulatory domain of ARAFadjacent to the functionally validated N217I mutation (Sia et al., 2015), which suggests an activated state.We also identified two frameshift deletions and one missense mutation S217F(Zou et al., 2014) in the albumingene (ALB), one of the most significantly mutated genes in HCC(Schulze et al., 2015).