METTL3 and neoplasm: Compared to mice grafted with control cells, mice transplanted with PBT003 cells having METTL14 KD or METTL3 and METTL14 double KD developed much bigger tumors, as revealed by a dramatic increase in tumor luciferase activity at week 4, 5, or 6 after GSC transplantation (Figures S4B and S4C).