Similar to what was observed for the PBT707 cell line, when luciferase-expressing PBT003 cells were transduced with METTL3 shRNA and then transplanted into the brains of NSG mice (Figure S3A), a dramatic increase in tumor progression, as revealed by elevated tumor luciferase activity, was detected when compared to that in mice transplanted with PBT003 cells transduced with a control shRNA (Figures S3B and S3C). Here, METTL3 is linked to neoplasm.