METTL3 and neoplasm: By transplanting METTL3 small hairpin RNA (shRNA) or METTL14 shRNA-transduced GSCs into immunodeficient non-obese diabetic (NOD) severe combined immunodeficiency (SCID) gamma (NSG) mice, we show that KD of METTL3 or METTL14 expression led to substantial increase of GSC-initiated tumor progression in transplanted mouse brains.