These tools are annexin-1 expression by immunohistochemistry, which is the most sensitive and specific immunophenotypic marker of HCL,61,62 and BRAF-V600E detection in HCL (but not HCL-like neoplasms) by molecular techniques on blood or marrow specimens (aspirates, smears, or fixed biopsies) or by immunohistochemical staining of fixed biopsies (Fig 2).19,20,24-37. The gene discussed is BRAF; the disease is neoplasm.