We addressed the same question of whether human luminal progenitor cells can function as a cell of origin for PCa by first purifying out Trop2+CD49flo luminal cells and, for comparison, Trop2+CD49fhi basal cells, from benign prostate tissue samples and then established 3D organoids (Fig. 1A). Here, TACSTD2 is linked to posterior cortical atrophy.