Two missense variants in strong LD (r2 = 0.82), rs1051168 in Neuromedin B (NMB, c.217C>A, p.Pro73Thr, MAF = 0.30) and rs3803403 in alpha-kinase 3 (ALPK3, c.1241C>G, p.Thr414Ser, MAF = 0.30) are associated with DCM at this locus. The gene discussed is ALPK3; the disease is familial dilated cardiomyopathy.