Three of the DCM-associated genes, FLNC, TTN (through its kinase activity) and cardiac specific FHOD3 encode maintenance partners of sarcomere and sarcomere-related structures, including Z-disk or F-actin myofibrils [29,38,39], which are disorganized or degraded in experimental models of cardiomyopathy [40]. Here, FLNC is linked to familial dilated cardiomyopathy.