The lead SNV, rs10927875 (ZBTB17, c.-3+222G>A, MAF = 0.31), is located in an intron of ZBTB17. As observed in our earlier GWAS [3], this SNP confers a reduced risk of DCM (OR = 0.77 (0.71–0.83), P = 8.1x10-13). This evidence concerns the gene ZBTB17 and familial dilated cardiomyopathy.