GLA and Fabry disease: Anderson-Fabry disease (AFD) is an X-linked recessive inborn error of glycosphingolipid metabolism caused by deficiency of alpha-galactosidase A (AGAL) which has an incidence estimated at 1 in 117,000 live births for males [1]; although a recent study suggest that the incidence may be much higher, particularly when non-classical phenotype is considered [2].