There were more studies evaluating agalsidase beta (41.2%, n = 31) with a total of 3,598 patients) followed by agalsidase alfa (37.6%, n = 29 with a total of 2,840 patients), and untreated patients, including natural history period of AFD patients and healthy volunteers (25.9%, n = 20 with a total of 8,865 patients). The gene discussed is GLA; the disease is Nager acrofacial dysostosis.