TNF and Sepsis: With the aggravation of the disease, the levels of pro-inflammatory cytokine IL-8 was significantly decreased in the septic AKI compared with sepsis-non AKI group, but still higher than the normal control group; and the levels of pro-inflammatory cytokines TNF-α, IL-1β and IL-6 gradually increased, significantly higher than the normal control and sepsis-non AKI groups; anti-inflammatory cytokines IL-10 was significantly increased in the septic AKI compared with sepsis-non AKI and control group.