TRPC4 and renal cell carcinoma: Though ceramides inhibit the L-type calcium channels [68], as englerin A was recently reported to do [26], it is unlikely that ceramides mediate this effect of englerin A. Modulation of L-type calcium channels by englerin A occurred at micromolar levels (Ki = 5.7 μM) while ceramides accumulate significantly in cc-RCC cells at nanomolar concentrations of englerin A. Ceramides were not found to modulate the TRPC4/5 channels and thus do not mediate englerin A activation of TRPC4/5 channels [71].