Semen coicis shows analgesic and anti-inflammatory properties.[53,54] Stigma maydis (corn silk), which contain saponin, alkaloid, flavones, volatile oil, mucilage, Vitamins B, C, and K, Silicon, increases the urinary output and the percentage the passage of urinary stones through the urinary tracts without decomposed stones, lower the total amount of acid in the urine,[55,56] and inhibit xanthine oxidase,[57] Therefore, Stigma maydis play an active role in treating gout by inhibiting the production of sUA, promoting the excretion of UA, and preventing the formation of kidney stones. This evidence concerns the gene XDH and nephrolithiasis.