Evidences exhibit that IL-6 plays an important role in the transformation of prostate cancer from hormone-dependent to hormone-independent, thus attenuating the efficiency of endocrine therapy.[35] As a pleiotropic cytokine, IL-6 can regulate many cell functions, including immune defensive mechanism, cell proliferation, and differentiation, and also the production of haemocytes. The gene discussed is IL6; the disease is prostate cancer.