First, experimental restoration of wild‐type p53 functions induces significant antitumor responses in mouse models, with a variety of underlying mechanisms of tumor regression in different tumor types (Feldser et al., 2010; Hill et al., 2015; Junttila et al., 2010; Martins et al., 2006; Ventura et al., 2007; Xue et al., 2007). The gene discussed is TP53; the disease is neoplasm.