In HCT116p53+/+ tumor cells, the impact of DIMP53‐1 on DNA damage was analyzed by checking comet‐positive cells and histone H2AX phosphorylated on serine 139 (γH2AX; phosphorylation of histone H2AX marks the first step in cellular response to DNA double‐strand breaks, and its visualization allows the assessment of DNA damage). Here, H2AX is linked to neoplasm.