Treatment of PIK3CA‐H1047R mouse tumor cells and RDR‐C234 with XAV939 (1, 5, and 10 μm) or S31‐201 (3, 15, and 30 μm) alone had no effect on cytotoxicity (Fig. S3), while the cells were sensitive to the combination of PI3K and STAT3 inhibitors (Fig. 5A a, b). The gene discussed is PIK3CA; the disease is neoplasm.