IGF1R and neoplasm: In addition, H1047R mouse tumor cells, RDR‐C234 and RDR‐A677, derived from recurrent tumors, responded more efficiently to a combination of inhibitors of PI3K (both LY294002 and GDC‐0941) and IGF‐1R (OSI‐906) in comparison with single treatments (Fig. 5C).