Here, we have demonstrated that the use of specific inhibitors to the pathways which we identified as induced in PIK3CA‐mutant tumors, such as STAT3, β‐catenin, and IGF‐1R, potentiates the cytotoxic effect of PI3K inhibitor on mutant PIK3CA tumor cells (Fig. 5). The gene discussed is STAT3; the disease is neoplasm.