Analysis of 965 primary breast tumors from TCGA RNA‐seq dataset showed that breast tumors harboring H1047R and other PIK3CA mutations (including E545K and E542K) have significant upregulation of AXIN2, HGF, STAT3, IGF‐1, and IGF‐2 mRNA compared with PIK3CA‐wild‐type and HER‐2‐amplified tumors (Fig. 6A). This evidence concerns the gene IGF2 and breast neoplasm.