The representative image, shown in Fig. 3(B), illustrates that in IGF‐1‐deficient mice, hypertension was associated with strong MMPsense 645 FAST fluorescence (indicating MMP activation) localized mainly to the media of small intracerebral arteries (identified by the intraluminal FITC–dextran fluorescence). This evidence concerns the gene IGF1 and hypertensive disorder.