Previous research demonstrated that rodent models with decreases of circulating IGF‐1 levels also exhibit aging‐like vascular phenotypes including cerebromicrovascular autoregulatory dysfunction, manifestation of intracerebral hemorrhages, neurovascular uncoupling, increased vascular oxidative stress, dysregulation of genes encoding the ECM, and impaired functional adaptation of cerebral arteries to hypertension (Bailey‐Downs et al., 2012; Sonntag et al., 2013; Toth et al., 2014, 2015a; Tarantini et al., 2016a,b). Here, IGF1 is linked to hypertensive disorder.