IGF1 and hypertrophic cardiomyopathy 1: We found that gait abnormalities (including a significant decline in regularity index, speed, and stride length; Fig. 2A–C, respectively) were significantly more severe in hypertensive IGF‐1‐deficient mice as compared to hypertensive control mice, suggesting that analysis of motor function status (e.g., deficit in interlimb coordination, temporal asymmetry) can predict the severity of CMH burden (Toth et al., 2015b).