In addition, one patient with hypogonadotropic hypogonadism and adrenal insufficiency (later treated by hydrocortisone) was found to harbor a hemizygous mutation of the NR0B1 gene (P01), and one patient with androgen insensitivity syndrome was found to harbor a hemizygous mutation of the AR gene (P21). This evidence concerns the gene NR0B1 and Adrenal insufficiency.