Through analysis of disorders in 33,332 cases and 27,888 controls, the consortium has identified shared geneticvariants on chromosomes 3p21 and 10q24 and within the genes for two L-type voltage-gated calcium channel subunits, CACNA1C and CACNB2. On the basis of GWAS data for schizophrenia, major depressive disorder and bipolar disorder, PGRS conferred by the additive effects of many common variants shows cross-disorder associations among adult-onset disorders (schizophrenia, major depressive disorder and bipolar disorder). This evidence concerns the gene CACNB2 and major depressive disorder.