Multivariate analysis with Cox regression hazard model was performed to better verify the significance of TBL1XR1 (Table 3), which demonstrated that its expression in primary CRC tissues was an independent prognostic factor for DFS of stage IV CRC patients (HR = 2.49, 95% CI 1.14–5.42, P = 0.022). This evidence concerns the gene TBL1XR1 and colorectal carcinoma.