PTEN and cancer: Mutations affecting many of these lipid phosphatases are linked to diseases such as Cowden and cancer for PTEN [17], Lowe syndrome for the OCRL1 [18], Joubert and MORM syndromes (two ciliopathies) for the INPP5E [19,20] and Parkinson’s disease for the Synaptojanin 1 [21,22].