LDLR and Impaired glucose tolerance: However, in a recent study with a relatively short duration (16–20 weeks), LDL-R−/− mice fed diets that provided more calories from fat (58%–60%) and fewer calories from carbohydrate (20%–28%) than our Western-type diet (40 kcal% fat and 43 kcal% carbohydrate) showed inflammation in both liver and adipose tissue, accompanied by IR and impaired glucose tolerance [43].