AKT1 and chronic obstructive pulmonary disease: Furthermore, blunted signaling through the Akt‐mTORC1 axis has been shown in hypoxia treated cells [Caron et al., 2009], rodents [Favier et al., 2010; de Theije et al., 2013], and individuals suffering from COPD [Favier et al., 2010] as well as myotubes in vitro derived from COPD muscle [Pomiès et al., 2015].