In addition to potentially lowering liver fat, short-term omega-3 FA treatment has been reported to improve whole-body insulin sensitivity.8, 9 However, the effects of omega-3 FA on insulin sensitivity in the context of NAFLD remains unclear, as some studies report neutral or negative results,10, 11 despite a concomitant reduction in NAFLD severity.12 This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.