It is noteworthy that although cytokine production was similarly impaired in Orai1- and Orai1/Orai2-deficient T cells (Fig. 8f), only mice that had received Orai1/Orai2-deficient T cells were fully protected from colitis, which is likely explained by the combination of abrogated cytokine production, proliferation and decreased tissue homing, all of which were more pronounced in Orai1/Orai2-deficient compared to Orai1-deficient T cells. The gene discussed is ORAI1; the disease is colitis.