STIM1 and Splenomegaly: By contrast, combined deletion of both Orai1 and Orai2 in T cells caused splenomegaly and lymphadenopathy in Orai1fl/flOrai2−/−Cd4cre mice at >3 months of age with elevated numbers of immune cell populations in the spleen and LNs (Fig. 5a and Supplementary Fig. 5e), which is reminiscent of the phenotype observed in animals with combined T cell-specific deletion of Stim1 and Stim2 (ref. 39).