Several members of the ADAM family including ADAM9, ADAM10, ADAM12, ADAM15, ADAM17 and ADAM23 have been implicated in the pathogenesis and progression of cancer, which occurs via the cleavage of different components, the direction of cell migration and the control of various signaling pathways that are activated in cancer cells22, 23, 24, 25, 26, 27. The gene discussed is ADAM15; the disease is cancer.