ADAM33 and neoplasm: Nevertheless, the decrease in ADAM33 protein might be an important mechanism of tumor progression because it has been shown to be correlated with a high risk of metastasis development (HR 0.581; 95% CI 0.365 to 0.923, p = 0.021) and overall survival (HR 0.464; 95% CI 0.253 to 0.848, p = 0.013) in our multivariate analysis (Table 3); moreover, was also found to be correlated with aggressive tumor, which corresponds to TNBC and BLBC.