FLT3 and acute myeloid leukemia: In a study of 39 CN-AML patients by Aly et al. [22], the frequency of FLT3-ITD was reported to be 15.4%, while Fröhling et al. [23] and Kainz et al. [24] found that the frequency of FLT3-ITD was 32% and 30% in CN-AML patients, respectively.