BMI body mass index, LVEF left ventricular ejection fraction, PCI percutaneous coronary intervention, CABG coronary artery bypass grafting, COPD chronic obstructive pulmonary disease, NYHA New York Heart Association, ACE angiotensin-converting enzyme, ARB angiotensin receptor blocker, eGFR estimated glomerular filtration rate, BNP B-type natriuretic peptide, NT-proBNP N-terminal pro B-type natriuretic peptide. The gene discussed is ACE; the disease is chronic obstructive pulmonary disease.