As described for the first time by Alois Alzheimer in 1906, the AD brain is characterized by the presence of two main pathological hallmarks: amyloid plaques, which are extracellular aggregates of an amyloid-beta (Aβ) peptide [3], and intraneuronal neurofibrillary tangles (NFT), which are mainly composed of hyperphosphorylated tau protein [4]. Here, MAPT is linked to Alzheimer disease.