ALK and non-small cell lung carcinoma: Currently, the only approved second-line therapies for patients who do not harbor identifiable driver oncogenes, such as epidermal growth factor receptor (EGFR) gene mutations or anaplastic lymphoma kinase (ALK) gene translocations, are docetaxel, gemcitabine, pemetrexed (limited for non-squamous NSCLC), and erlotinib (6–9).