INS and Alzheimer disease: As shown in Figure 5(a), the pathway map depicted that the 168 differentially expressed proteins overlapped in Figure 2(a) were related to Toll-like receptor signaling pathway, Alzheimer's disease, cytosolic DNA-sensing pathway, spliceosome, RIG-I-like receptor signaling, apoptosis, cell cycle, insulin signaling pathway, Huntington's disease, calcium signaling pathway, and pathways in cancer.