Since the association of IL1RA and IL4 VNTRs with obesity and its related parameters is still elusive especially in Asians, the objectives of this study are therefore to investigate the distribution of IL1RA and IL4 VNTRs genotypes and alleles and to determine whether they are associated with overall obesity (as measured by BMI), central adiposity (as measured by waist circumference, WC), and overall adiposity (as measured by total body fat, TBF) in Malaysian subjects. This evidence concerns the gene IL1RN and obesity disorder.