A review by Witkin et al. 2002 [10] summarized that individuals homozygous for allele II have more prolonged and severe proinflammatory immune response than persons with other IL1RA genotypes, which might be beneficial when combating infectious agents [39] or neoplasms [40], but is detrimental for those with chronic inflammatory conditions [41] or those who are pregnant [42]. The gene discussed is IL1RN; the disease is neoplasm.