IL1B and obesity due to melanocortin 4 receptor deficiency: Specifically, anti-inflammatory cytokines interleukin- (IL-) 13, IL-4, and IL-10 stimulate the alternatively activated ATMs (M2) in lean persons, while obesity induces a shift to the classically activated ATMs (M1) due to stimulation by proinflammatory cytokines TNF-α, IL-1β, and IL-6 [3].