RNA-binding motif protein 3 (RBM3) is an RNA and DNA binding protein that has previously been shown to be upregulated in cancer tissues compared with normal tissue [16], but to be associated with favourable prognosis in several major cancer forms such as breast, ovarian, prostate, testicular, esophageal, colorectal cancer and malignant melanoma [17–25]. This evidence concerns the gene RBM3 and melanoma.