Accordingly, the present study aimed to (1) isolate the IGF from V. ciliata by HSCCC; (2) characterize the chemical composition of the IGF by ultra-performance liquid chromatography (UPLC) analysis; and (3) assess the antioxidant activity in vitro and the hepatoprotective effects in vivo using an APAP-induced murine model of ALI. Here, IGF1 is linked to acute respiratory distress syndrome.