CFTR and fibrosis: Macrophages from CLIC1-/- mice display a defect in phagosome acidification (Jiang et al., 2012), and lysosome acidification is defective in alveolar macrophages from mice lacking the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) (Di et al., 2006), a chloride channel, suggesting that these channels might transport Cl- into granules in these cells.